Basic Information
VIS ID
TVIS44009075
Fusion event
HTLV-1-CORO2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
100883940/98121658 (Hg38)
End
100883940/98121658 (Hg38)
Orient
-
Location type
UTR3
Target gene
CORO2A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-6778-3p ; hsa-mir-6128 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-3691-3p ; hsa-mir-4279 ; hsa-mir-8081 ; hsa-mir-1231 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-516b-5p ; hsa-mir-7977 ; hsa-mir-3120-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-4267 ; hsa-mir-6736-3p ; hsa-mir-5588-3p ; hsa-mir-29b-2-5p ; hsa-mir-3187-3p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-4755-3p ; hsa-mir-29b-1-5p ; hsa-mir-4507 ; hsa-mir-3940-5p
Nearest miRNA
hsa-let-7a-1/Upstream/757977; hsa-mir-12126/Downstream/107491;
Nearest TSS
ENST00000422679/Upstream/2446; ENST00000610463/Downstream/51226;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/2280, chr9-CpG: 24/Downstream/70346
Upstream sequence
TGTTTGTTAAGTGTGCAGTCTGGGTCCCTTGGGGTGGAGGGAGCTGGCCAAGGAATGGCATTGTGCAGAGGCATACcgggaagctctctggatgcaaccc
Downstream sequence
cacctctaccgcttggcagtcaatgaccttggcatgatgtttcttcacttctctgaggctaggtctttgattctgaacatggggactgtaatgcctgcct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate