Basic Information
VIS ID
TVIS44009085
Fusion event
HTLV-1-OTUD7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
32030743/31738540 (Hg38)
End
32030743/31738540 (Hg38)
Orient
-
Location type
Intronic
Target gene
OTUD7A
miRNAs that regulate target gene
hsa-mir-30c-5p ; hsa-mir-491-3p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-1255b-2-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5582-3p ; hsa-mir-1238-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-153-5p ; hsa-mir-670-3p ; hsa-mir-8080 ; hsa-mir-1197
Nearest miRNA
hsa-mir-1268a/Upstream/673399; hsa-mir-10393/Downstream/2643529;
Nearest TSS
ENST00000557528/Upstream/83201; ENST00000636184/Downstream/132038;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/253755, chr15-CpG: 177/Downstream/131421
Nearby gene
OTUD7A(-83201) ;
Upstream sequence
CAAAAGAGGTCCAGGGAGGGAGATCAGTTGCCTGCATCCTCCTTGGAGCAATCCCATAGTTTCCAAGGGTCCCAGAGGCATTCTGATAGAGCATGACAGT
Downstream sequence
GATCCCTAATTTGACAACCCAGGAGGATTATCTGCCATGACAGTTTTCTGTGGAGGAAAGGACCAGCACCTATGCTGCCTCCGCTGATAGGGCTGTTACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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