Basic Information
VIS ID
TVIS44009109
Fusion event
HTLV-1-UBE4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
10227506/10167448 (Hg38)
End
10227506/10167448 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
UBE4B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-3p ; hsa-mir-92a-3p ; hsa-mir-6885-3p ; hsa-mir-3926 ; hsa-mir-1251-3p ; hsa-mir-4753-5p ; hsa-mir-9-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-6870-5p ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4668-5p ; hsa-mir-3202 ; hsa-mir-3148 ; hsa-mir-3179 ; hsa-mir-873-5p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6783-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-2681-5p ; hsa-mir-607 ; hsa-mir-29b-2-5p ; hsa-mir-580-3p ; hsa-mir-3671 ; hsa-mir-584-5p ; hsa-mir-6798-3p ; hsa-mir-186-3p ; hsa-mir-4762-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-12136/Upstream/199990; hsa-mir-101-1/Downstream/1861710;
Nearest TSS
ENST00000473358/Upstream/9094; ENST00000465408/Downstream/3508;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/134102, chr1-CpG: 156/Downstream/42509
Nearest cancer related gene
UBE4B(TSG, No orient, 0)
Upstream sequence
gaatcacttgaacctgggaggcggaggttccggtgagccgagatcgcgccattgcactccagcctgggcaacaagcgaaactccgtctcaaaaaataata
Downstream sequence
ataataataataataataataataatGACTAAGTAAAAGTTATTATTAAGGGAAATAAACTACCCTTTCTTAGTGCCATGATGTGTGTCAGATACTATGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate