Basic Information
VIS ID
TVIS44009115
Fusion event
HTLV-1-MIER1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
67451452/66985769 (Hg38)
End
67451452/66985769 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA1L
Target gene
MIER1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30e-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-580-3p ; hsa-mir-4324 ; hsa-mir-4251 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3686 ; hsa-mir-190a-3p ; hsa-mir-298 ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-922 ; hsa-mir-5586-5p ; hsa-mir-410-3p ; hsa-mir-5197-3p ; hsa-mir-450b-5p ; hsa-mir-4511 ; hsa-mir-4696
Nearest miRNA
hsa-mir-101-1/Upstream/357252; hsa-mir-11399/Downstream/1197749;
Nearest TSS
ENST00000473358/Upstream/26858; ENST00000637002/Downstream/68330;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/54969, chr1-CpG: 59/Downstream/68093
Upstream sequence
TTTTATGAGAGGAATTGTTATTCTGAGTCTGTCAGCTTTCATTTTATTTTGCTAAGGTTTTTCTAATGAATTTTTAAGTGTTTGTGTAGTAATTAAGTCA
Downstream sequence
TATTTCTTATCCAGGTGGTTAAAGCATTCATAAAGGATTATAAAAtttttttttttttttttttttttAAATTTCTACTTAAGGGCAAGTAATTTGAGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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