Basic Information
VIS ID
TVIS44009118
Fusion event
HTLV-1-PRKACB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
84545491/84079808 (Hg38)
End
84545491/84079808 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
PRKACB
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-203a-3p ; hsa-mir-106b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-20b-5p ; hsa-mir-520e ; hsa-mir-520f-3p ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-519d-3p ; hsa-mir-520d-3p ; hsa-mir-513a-3p ; hsa-mir-636 ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-302e ; hsa-mir-513c-3p ; hsa-mir-548x-5p ; hsa-mir-3606-3p ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-1273e ; hsa-mir-3660 ; hsa-mir-548aj-5p ; hsa-mir-4526 ; hsa-mir-548aw ; hsa-mir-3692-3p ; hsa-mir-7158-3p ; hsa-mir-1468-3p ; hsa-mir-2277-3p ; hsa-mir-4539 ; hsa-mir-4724-5p ; hsa-mir-3120-3p
Nearest miRNA
hsa-mir-101-1/Upstream/7019606; hsa-mir-11399/Downstream/1053986;
Nearest TSS
ENST00000473358/Upstream/1664; ENST00000467507/Downstream/64463;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1230, chr1-CpG: 77/Downstream/218617
Upstream sequence
aggctggagtgcaatggtgcaatcttggctcactgcaacctctgcctcccaggttcaagggattctcctgcctcagcctcctgagtagctgggattacag
Downstream sequence
gtgcccaccaccacacccggctaatttttgtatttttagtagagacagagtttcaccatgttggtcaggctggtctcgaactcctgacctcaggtaatcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate