Basic Information
VIS ID
TVIS44009124
Fusion event
HTLV-1-MAN1A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
GRCh37/hg19
Start
117931745/117389123 (Hg38)
End
117931745/117389123 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAN1A2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-30a-5p ; hsa-mir-130b-3p ; hsa-mir-541-5p ; hsa-mir-3653-3p ; hsa-mir-6869-5p ; hsa-mir-496 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-4455 ; hsa-mir-640 ; hsa-mir-6867-5p ; hsa-mir-4286 ; hsa-mir-4262 ; hsa-mir-216b-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-1277-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-4662a-3p ; hsa-mir-4662a-5p ; hsa-mir-6124 ; hsa-mir-6832-5p ; hsa-mir-6859-5p ; hsa-mir-8081
Nearest miRNA
hsa-mir-101-1/Upstream/294395; hsa-mir-1182/Downstream/28461464;
Nearest TSS
ENST00000473358/Upstream/21180; ENST00000449370/Downstream/31474;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/21300, chr1-CpG: 135/Downstream/216213
Upstream sequence
GTAAAGGATCTTTATGGTGATCAGAAATCCACTTCAACTTTTATCCTTTATACTTCAAAATGTCAATGAGAATGACTACTTAAAATACCAAATCCCATCT
Downstream sequence
AAAACAACCCCCCAAAATCTCATAAAATATTGAAGCTAAAAGAAAGAACGAGTTACTATGTGCATGATAGTTTCTTCTTTTTCCTTTGGGTTTTATACCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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