Basic Information
VIS ID
TVIS44009148
Fusion event
HTLV-1-LOC105378305 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
54476139/52716379 (Hg38)
End
54476139/52716379 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
LOC105378305
Nearest miRNA
hsa-mir-1265/Upstream/1416724; hsa-mir-107/Downstream/1891495;
Nearest TSS
ENST00000439456/Upstream/155274; ENST00000422842/Downstream/39030;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/305161, chr10-CpG: 18/Downstream/155072
Nearby gene
MBL2(-49001) ;
Upstream sequence
AAATAAATACGTTGAGAGAGTGAAAAAGGCAAAACTATGGTTACCCTGAAGAGGTGAACCCCCAAAACACTGTAATAGCAGAAAACAGTAAGGCAGTTTG
Downstream sequence
ATAAGCATTTTGCAAAAACATGATCTATTGAATATTGGTAGGTTATGTAAGAGGTACATAGACATGGTCCTACTTTGCAAGGGGTTCATCATCTGAGTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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