Basic Information
VIS ID
TVIS44009151
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
85006226/83246470 (Hg38)
End
85006226/83246470 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D
Nearest miRNA
hsa-mir-1265/Upstream/7693917; hsa-mir-107/Downstream/3018224;
Nearest TSS
ENST00000439456/Upstream/446728; ENST00000372134/Downstream/428969;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1370497, chr10-CpG: 24/Downstream/318473
Nearby gene
NRG3(+259291) ;
Upstream sequence
GTACATTCTCATTTGCTACAGTCTCCTAGCTGGTGTAGGAAGCAGGTAATCTAATTTTTCTTAGAAAGTAGCACTATGAATAATTTAACAAGTGTTTGCC
Downstream sequence
CTCAGGAAAATATTGAATTTAGAGCTTTTTGCAAATAAATCAATATAAGAACAAATCCTACAATAGTTAATTTTTAGGAAAAATGTCCAGGCATAGGGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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