Basic Information
VIS ID
TVIS44009155
Fusion event
HTLV-1-ARHGAP19-SLIT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
98987953/97228196 (Hg38)
End
98987953/97228196 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ARHGAP19-SLIT1
miRNAs that regulate target gene
hsa-mir-211-3p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4530 ; hsa-mir-617 ; hsa-mir-6510-5p ; hsa-mir-6858-3p ; hsa-mir-761
Nearest miRNA
hsa-mir-107/Upstream/399432; hsa-mir-1287/Downstream/647617;
Nearest TSS
ENST00000439456/Upstream/42276; ENST00000490980/Downstream/28319;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/31668, chr10-CpG: 48/Downstream/63981
Upstream sequence
GACAGAAGCAACGAGGAAAGAAAAGAGAGTTTAGATAATTCATTCAAGGATAAGTAAGAAGAATATACTGAAATCTAATTTTCCAGAAAAGAATTTATCC
Downstream sequence
ATAAGGATTAGGCTTTTGATCTCTGCCTATTGCTGATGTCTCAAATAGTAATTATGCTCATATCCCAGTGATAAAACAATCATGTCAAACCAGACTCACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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