Basic Information
VIS ID
TVIS44009157
Fusion event
HTLV-1-CASP7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
115445334/113685575 (Hg38)
End
115445334/113685575 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
CASP7
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-132-3p ; hsa-mir-122-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-106a-5p ; hsa-mir-146a-5p ; hsa-mir-224-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-107/Upstream/1051321; hsa-mir-202/Downstream/92418;
Nearest TSS
ENST00000439456/Upstream/5635; ENST00000468790/Downstream/6397;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5138, chr10-CpG: 66/Downstream/169039
Upstream sequence
tagttctattaatacttgttttatatatttaggtgtgctaatgttgatgcatatatatttacagttgttatgtctttggtaaattgatatctatagttat
Downstream sequence
aatataatgaccttctttatctcgaaagttttttactttagtctattttgtctgatataagtatagccccccctgctctcttttggttaccattcatatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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