Basic Information
VIS ID
TVIS44009160
Fusion event
HTLV-1-FANK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
127673318/125984749 (Hg38)
End
127673318/125984749 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
FANK1
Nearest miRNA
hsa-mir-107/Upstream/164927; hsa-mir-202/Downstream/3858550;
Nearest TSS
ENST00000439456/Upstream/9854; ENST00000477963/Downstream/3802;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/87780, chr10-CpG: 132/Downstream/402837
Upstream sequence
atgaggctggattggaattctgggggagggagtttagagaagaaagggaagtctggtaactgagtcttggggcttttcaatatttaTTTAGCTTCTTATG
Downstream sequence
TTTCATATTTGCTCAGCTCTTGCATCAAACATTTGCTTATTGACTGATAACAAAAACAAGGCTATGCTTTAAATTTTTGTAGACTTTCCTCTACTGTGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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