Basic Information
VIS ID
TVIS44009165
Fusion event
HTLV-1-CCDC34 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
27379963/27358416 (Hg38)
End
27379963/27358416 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCDC34
miRNAs that regulate target gene
hsa-mir-21-5p
Nearest miRNA
hsa-mir-210/Upstream/3939226; hsa-let-7a-2/Downstream/156554;
Nearest TSS
ENST00000527297/Upstream/7992; ENST00000525833/Downstream/4818;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1026151, chr11-CpG: 29/Downstream/4656
Upstream sequence
ACACAAGCCTCATGAAACTGAGAAAAAGCTTAACAATCAGCAGCCATAGAAAGCAAGGTTGTTCAGGACATAAGGTAGCTCTAAAGACTAGTTTATTACA
Downstream sequence
GACTCAGTTCTTTGTCTCTTTCACATTCCTGCTTATAGCAACCAATTGCTTCACCCACTGCTTTGCACAACTTTTCTACTTCATAGATTCAGCTTACTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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