Basic Information
VIS ID
TVIS44009166
Fusion event
HTLV-1-BDNF-AS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
27541340/27519793 (Hg38)
End
27541340/27519793 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
BDNF-AS
miRNAs that regulate target gene
hsa-mir-3942-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-589-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-205-3p ; hsa-mir-4519 ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-6870-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6739-5p ; hsa-mir-3153 ; hsa-mir-6733-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4786-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-210/Upstream/4746; hsa-let-7a-2/Downstream/537022;
Nearest TSS
ENST00000527297/Upstream/12941; ENST00000530313/Downstream/114729;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/12823, chr11-CpG: 80/Downstream/180321
Upstream sequence
gtatacaaaatatcaatattgtattgtgtttgctaaagtgtttattttccccaaccagagagtgagccccttcacggctaagaatggcattgtaatcatc
Downstream sequence
actgactctccagcaggtagcaaagcatattaccgaagctccttgatcatttgctgaatgaaCCATGGGTAATAAAATCAGTGAGTGGCAGAAAGATTGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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