Basic Information
VIS ID
TVIS44009172
Fusion event
HTLV-1-AMBRA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46503724/46482174 (Hg38)
End
46503724/46482174 (Hg38)
Orient
-
Location type
Intronic
Target gene
AMBRA1
miRNAs that regulate target gene
hsa-mir-339-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-1231 ; hsa-mir-1299 ; hsa-mir-1343-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-24-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-3928-5p ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4533 ; hsa-mir-485-5p ; hsa-mir-555 ; hsa-mir-571 ; hsa-mir-6128 ; hsa-mir-6134 ; hsa-mir-6515-5p ; hsa-mir-6758-5p ; hsa-mir-6776-5p ; hsa-mir-6783-3p ; hsa-mir-6796-3p ; hsa-mir-6806-3p ; hsa-mir-6851-5p ; hsa-mir-6856-5p ; hsa-mir-6861-5p ; hsa-mir-6881-5p ; hsa-mir-6884-5p ; hsa-mir-759 ; hsa-mir-875-3p
Nearest miRNA
hsa-mir-129-2/Upstream/30285; hsa-let-7a-2/Downstream/270951;
Nearest TSS
ENST00000527297/Upstream/64179; ENST00000579280/Downstream/11719;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/89037, chr11-CpG: 45/Downstream/111473
Upstream sequence
gttttgttttgttgttgttgtttttgcttaggattgctttggctattcaggctcttttctggctccctatgaattttaggattgtttttctctaTAATAC
Downstream sequence
TACTTCATGGCCAAATCTAAGCTTGAGTTACTAAATTCTGTCTTTTCACTACCCCTCTGCAGTTCAGCATGATGGGCAATGTTTTGGATAATTGTAAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate