Basic Information
VIS ID
TVIS44009182
Fusion event
HTLV-1-HIGD1AP10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64912717/65145246 (Hg38)
End
64912717/65145246 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
HIGD1AP10
Nearest miRNA
hsa-mir-10392/Upstream/15268; hsa-let-7a-2/Downstream/299212;
Nearest TSS
ENST00000527297/Upstream/10713; ENST00000377185/Downstream/24908;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/10610, chr11-CpG: 64/Downstream/35998
Nearby gene
SYVN1(-10714) ;
Upstream sequence
TGTAAGCTTTCTAGATTTGGTTTAAACACACACACATAGATACTGTCAGTTGTGGGAAGCTTTACAAGTTTTATTCCATGCACTTTTTAGACAGAGTTCT
Downstream sequence
GAAAGAGCCAGCCAGTCCACAAGACAGGCAGAAAAAAAGTTAAATTAACTAGGGCAAATAGGACTCTTATATAACATCCGAAACATGTGAGATCCTGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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