Basic Information
VIS ID
TVIS44009184
Fusion event
HTLV-1-NDUFC2-KCTD14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77772115/78061069 (Hg38)
End
77772115/78061069 (Hg38)
Orient
-
Location type
Intronic
Target gene
NDUFC2-KCTD14
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-7152-5p ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-4777-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-376a-5p ; hsa-mir-4326 ; hsa-mir-567 ; hsa-mir-643 ; hsa-mir-1266-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-144-3p ; hsa-mir-1227-3p ; hsa-mir-5189-3p ; hsa-mir-6889-3p ; hsa-mir-2115-3p ; hsa-mir-551b-5p
Nearest miRNA
hsa-mir-10392/Upstream/2725883; hsa-let-7a-2/Downstream/1340953;
Nearest TSS
ENST00000527297/Upstream/14878; ENST00000281030/Downstream/2792;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/37892, chr11-CpG: 64/Downstream/18363
Upstream sequence
actccagcctgagcgacagagtgacaccctgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaGCTCAAGGTTAAAAAAAAAGAACTTTGCATATATAACTT
Downstream sequence
AGCTTAGAATAATATGTCTTCAGTTATTGTTTGCCCTTATCATTATTACAACATATGAGGATGTCGAGGCTCAGGGAGGCTGGTGCTCTCTGTTTCCCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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