Basic Information
VIS ID
TVIS44009195
Fusion event
HTLV-1-B4GALNT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
592296/483130 (Hg38)
End
592296/483130 (Hg38)
Orient
-
Location type
Intronic
Target gene
B4GALNT3
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-378a-3p ; hsa-let-7a-5p ; hsa-mir-521 ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-2115-5p ; hsa-mir-6832-3p ; hsa-mir-6878-3p ; hsa-mir-6873-3p ; hsa-mir-6749-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5088-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-6507-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6851-3p ; hsa-mir-6886-3p ; hsa-mir-1915-5p ; hsa-mir-3667-3p ; hsa-mir-877-3p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-506-3p ; hsa-mir-124-3p
Nearest miRNA
hsa-let-7i/Downstream/1177185;
Nearest TSS
ENST00000382841/Upstream/22660; ENST00000540836/Downstream/57333;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/21934, chr12-CpG: 35/Downstream/86663
Upstream sequence
ctgagtagctggcactacaggtggatgtcacctcatccagctaattttttttttccctttggagagacagggtcttaccgtgttgcccaggctggtcttg
Downstream sequence
aactcctgggttcaagcactcctaccacctcagtctcccaaagtgctgggattatggacataagccaGGATGCACGGTTGTAGGTGTTATTCTTTAAACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate