Basic Information
VIS ID
TVIS44009199
Fusion event
HTLV-1-ADAMTS20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
43825184/43431381 (Hg38)
End
43825184/43431381 (Hg38)
Orient
-
Location type
Exonic
Target gene
ADAMTS20
miRNAs that regulate target gene
hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-22-5p ; hsa-mir-2116-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1107522; hsa-let-7i/Downstream/3756431;
Nearest TSS
ENST00000382841/Upstream/276066; ENST00000546780/Downstream/8331;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/840803, chr12-CpG: 126/Downstream/119535
Upstream sequence
CTATTCTGTAAAGATAGATCAAATTAGAAAAACCCATATCATATACTCACAGGACCCCATGGTCCTACTTGCCAGGAAGCACATGTATGAAGTTCACATG
Downstream sequence
GACTCAGAGATTCAGGTTTGGTACTTGAATTACAGAAGCCATCACTCAAGTGATCTACATTCAGCTGACACCATACCTGCCGCTGCTTTGTTCCTTTACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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