Basic Information
VIS ID
TVIS44009204
Fusion event
HTLV-1-E2F7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
77458839/77065059 (Hg38)
End
77458839/77065059 (Hg38)
Orient
-
Location type
Intronic
Target gene
E2F7
miRNAs that regulate target gene
hsa-mir-26a-5p ; hsa-mir-125a-5p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-10a-5p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-125b-5p ; hsa-let-7b-5p ; hsa-mir-4282 ; hsa-mir-6798-3p ; hsa-mir-95-5p ; hsa-mir-3163 ; hsa-mir-3942-5p ; hsa-mir-4703-5p ; hsa-mir-548at-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-6792-5p ; hsa-mir-548e-5p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-424-5p ; hsa-mir-15b-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-1297 ; hsa-mir-3144-3p ; hsa-mir-376a-5p ; hsa-mir-376a-2-5p ; hsa-mir-643 ; hsa-mir-4431 ; hsa-mir-5697 ; hsa-mir-6831-5p ; hsa-mir-4640-3p ; hsa-mir-3927-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-196a-5p ; hsa-mir-196b-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-let-7i/Upstream/7480236; hsa-mir-1178/Downstream/2354198;
Nearest TSS
ENST00000382841/Upstream/14313; ENST00000552736/Downstream/491;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/185623, chr12-CpG: 91/Downstream/108
Upstream sequence
GGTCTCCCAGGTCAGTTAATTTTGGCGCAAAGAACTGAGAGGAATTCGGCTTTGAGGGGTTTTGAATCGGGGGAAGGAAACCCGATCGCTAGACCAAACC
Downstream sequence
CACTCAGCGCTGAGCGCAGCCCCTTCCCAGGCCTCCAAGCAGATCCCCCAAATAAACTTCTCCAATGAAAGCTCCAAGTTGTGGGGAAGGGCAAATCCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate