Basic Information
VIS ID
TVIS44009205
Fusion event
HTLV-1-chr12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
79245199/78851419 (Hg38)
End
79245199/78851419 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/9266596; hsa-mir-1178/Downstream/567838;
Nearest TSS
ENST00000382841/Upstream/47071; ENST00000549454/Downstream/12574;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/46799, chr12-CpG: 198/Downstream/838332
Nearby gene
SYT1(+12574) ;
Nearest cancer related gene
SYT1(OG, +12574) ;
Upstream sequence
ATGCTCAAAGTTTGTCCTTCATAATGTAAGTCCTGGCTAAAATTTCAAATTTATTTTGAGAACCCCAGTATACTCATCTACAGTTCTAAAGTTACTAAAG
Downstream sequence
TACTTGCAGTTCTTGGCTCCTTactcatggatttggtaaacatttattaagtacatattatctgccagtgtggactattttCTTTTGTGTGAATCTCTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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