Basic Information
VIS ID
TVIS44009211
Fusion event
HTLV-1-CHST11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
105081150/104687372 (Hg38)
End
105081150/104687372 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHST11
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-186-5p ; hsa-mir-98-5p ; hsa-mir-6761-5p ; hsa-mir-6510-5p ; hsa-mir-6731-5p ; hsa-mir-8085 ; hsa-mir-3185 ; hsa-mir-6125 ; hsa-mir-4719 ; hsa-mir-185-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-135b-3p ; hsa-mir-6824-5p ; hsa-mir-6867-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-7154-3p ; hsa-mir-6783-5p
Nearest miRNA
hsa-let-7i/Upstream/95656; hsa-mir-1178/Downstream/3948438;
Nearest TSS
ENST00000382841/Upstream/98524; ENST00000280749/Downstream/146807;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/228755, chr12-CpG: 18/Downstream/69612
Upstream sequence
CCAAGGGTTGTTGACTGAATTCGTAAAAGCACCTTACACATCAGAGGCACTAAGTAAATGTGTATAAATCCTGGACAATACAGCAATAGTGATGGTTAAT
Downstream sequence
AACAATGGTTCTcatttattgagcacttactatgtaccacacaccatgtgaagcgctttacctgagttatctcatctcaccgtccaaccactgcattaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate