Basic Information
VIS ID
TVIS44009215
Fusion event
HTLV-1-TPTE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
20054443/19480303 (Hg38)
End
20054443/19480303 (Hg38)
Orient
+
Location type
Intronic
Target gene
TPTE2
miRNAs that regulate target gene
hsa-mir-148b-3p
Nearest miRNA
hsa-mir-1267/Downstream/953475;
Nearest TSS
ENST00000623511/Upstream/70774; ENST00000438640/Downstream/22931;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/135222, chr13-CpG: 17/Downstream/79823
Nearest cancer related gene
TPTE2(TSG, No orient, 0)
Upstream sequence
GGGGGTAGGGAGGTGGCCATGATGTAAAGCATGAAAAACACTGTAGTGACTCTGGTCTTCCTGCTCACTCTAGATCACTAAAACAGGGTAAGGACAATAT
Downstream sequence
AGGGGGATGACATTTTCATGCTGAGAAAACTATGAGTCACTTAGGAGAAAAGTAAATTTCTACACTTTATACCTTAAGACAAAGTAAATTCAGGGCAGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate