Basic Information
VIS ID
TVIS44009236
Fusion event
HTLV-1-DACH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72198294/71624162 (Hg38)
End
72198294/71624162 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
DACH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-217
Nearest miRNA
hsa-mir-1297/Upstream/5405838; hsa-mir-1267/Downstream/6073850;
Nearest TSS
ENST00000623511/Upstream/609021; ENST00000618209/Downstream/242607;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1516075, chr13-CpG: 62/Downstream/241068
Nearest cancer related gene
DACH1(TSG, No orient, 0)
Upstream sequence
TAATGAAGAAAAATTGCCATAAATAGTAAATATTTAAAAATGCATTTAAATTGATGGAATAGTAGCTTAGTACATTTTTTGTCTTTTATTATTGGGGTAA
Downstream sequence
GCAATTTTGTGTAAAAATTTCAGGATATGAAGATATCTTTTGCATAGGGGATGATATTAACCATATGGCCTATTCTTAATCAATTGAATTACAAACCATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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