Basic Information
VIS ID
TVIS44009237
Fusion event
HTLV-1-TBC1D4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76054468/75480332 (Hg38)
End
76054468/75480332 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
TBC1D4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-19b-3p ; hsa-mir-29b-2-5p ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-1193 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-8069 ; hsa-mir-4456 ; hsa-mir-4494 ; hsa-mir-4463
Nearest miRNA
hsa-mir-1297/Upstream/9262008; hsa-mir-1267/Downstream/2217680;
Nearest TSS
ENST00000623511/Upstream/103038; ENST00000471792/Downstream/1782;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1344651, chr13-CpG: 197/Downstream/384
Upstream sequence
TACCAAAAGAAAGCCACATGGTGCAACCTGAGACTTTATTTATATTTAGACAACACTATTTTTCCAAAGAACCTAAAGTACTGTGCAAACAGTAAATAAC
Downstream sequence
CATTTTTAAAACAGCATTTTGGAAGCTTTTGATATGGCGGGGAGAAAACTCATTACAAATTAAAGGGGGAAAACTCTGTTTTCAAAGACACAATCACTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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