Basic Information
VIS ID
TVIS44009245
Fusion event
HTLV-1-ANG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
21152365/20684206 (Hg38)
End
21152365/20684206 (Hg38)
Orient
-
Location type
UTR5
Target gene
ANG
miRNAs that regulate target gene
hsa-mir-409-3p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-874-3p ; hsa-mir-3157-3p ; hsa-mir-6790-5p ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-18b-3p ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-3927-5p ; hsa-mir-454-5p ; hsa-mir-3922-5p ; hsa-mir-3142 ; hsa-mir-1245b-5p ; hsa-mir-574-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5580-3p ; hsa-mir-6839-5p ; hsa-mir-378j ; hsa-mir-5698 ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-7641 ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-4695-3p ; hsa-mir-6812-3p ; hsa-mir-5693 ; hsa-mir-6514-5p ; hsa-mir-6867-5p ; hsa-mir-93-5p
Nearest miRNA
hsa-mir-1185-1/Downstream/339108;
Nearest TSS
ENST00000550708/Upstream/29; ENST00000397990/Downstream/377;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1141, chr14-CpG: 24/Downstream/118
Upstream sequence
ACCCCCTTTTGTCAACTACTGAAAAAAAGTCTCCGTTAAATTTGAAACACAAACTGTCTCGCGATGGGCTGTCCTGCCAAAGAAAGCAGCAGCGAATAAG
Downstream sequence
TACGTGGCAGATGGTGCTGTCGACCAGTGTCAAGACCAAGTTTCATGGGTTCCTGGACGCTCAGCCAGGGGTAGTCTCTGAAGGGCCGCCTGGCAATTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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