Basic Information
VIS ID
TVIS44009253
Fusion event
HTLV-1-VASH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77245037/76778694 (Hg38)
End
77245037/76778694 (Hg38)
Orient
-
Location type
Intronic
Target gene
VASH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-720 ; hsa-mir-4534 ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4779 ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-6738-3p ; hsa-mir-6885-3p ; hsa-mir-3977 ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-152-5p ; hsa-mir-3667-3p ; hsa-mir-877-3p ; hsa-mir-5088-3p ; hsa-mir-133a-5p ; hsa-mir-138-5p ; hsa-mir-140-3p ; hsa-mir-1914-5p ; hsa-mir-3184-3p ; hsa-mir-3663-5p ; hsa-mir-5008-3p ; hsa-mir-6131 ; hsa-mir-6736-3p ; hsa-mir-6737-3p ; hsa-mir-6787-3p ; hsa-mir-6792-3p ; hsa-mir-6834-3p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-6856-3p ; hsa-mir-7157-3p
Nearest miRNA
hsa-mir-208a/Upstream/2298490; hsa-mir-1185-1/Downstream/487524;
Nearest TSS
ENST00000550708/Upstream/688; ENST00000553758/Downstream/258;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/2428, chr14-CpG: 76/Downstream/33536
Upstream sequence
GCCTCTGGCACCAAAATATCCATCATCTGTGACTTTTATCTAAGAGGCTTTTGTAGATGACAGATTCCCCTCAGACAGATTTATACTTTAAGCTGTTACC
Downstream sequence
TACCAACTGCAGCCAGATTAGCCAGCCTCCAGCAGCGAGAAAGCCTGTGAGAGCGAGCCGGGGCCACATTCAGACAGCACAGGCGGGCCAGGGTGTCCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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