VISDB - VIS Detail

Basic Information

VIS ID

TVIS44009269

Fusion event

HTLV-1-AQR integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr15

Cytoband

q14

Reference genome

GRCh37/hg19

Start

35151820/34859619 (Hg38)

End

35151820/34859619 (Hg38)

Orient

Location type

Intronic

Target gene

AQR

miRNAs that regulate target gene

hsa-mir-4326 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3122 ; hsa-mir-3913-5p ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-3682-3p ; hsa-mir-4294 ; hsa-mir-924 ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4252 ; hsa-mir-3130-3p ; hsa-mir-1273g-3p ; hsa-mir-941 ; hsa-mir-4438 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-3180-5p ; hsa-mir-4314 ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4277 ; hsa-mir-6874-3p ; hsa-mir-148b-5p ; hsa-mir-3649 ; hsa-mir-659-5p ; hsa-mir-767-5p ; hsa-mir-1915-3p ; hsa-mir-6764-5p ; hsa-mir-6872-3p ; hsa-mir-7113-5p ; hsa-mir-211-3p ; hsa-mir-6892-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-627-3p ; hsa-mir-6760-5p ; hsa-mir-4475 ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-8061 ; hsa-mir-665 ; hsa-mir-4760-5p ; hsa-mir-7106-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p

Nearest miRNA

hsa-mir-1233-1/Upstream/331248; hsa-mir-10393/Downstream/512637;

Nearest TSS

ENST00000557528/Upstream/63480; ENST00000560140/Downstream/3605;

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/104408, chr15-CpG: 34/Downstream/109866

Upstream sequence

taaattcagccattccactcttaggtatctacccaagataaaGTACAAAGACTTGTAtaagcaatagtagccagaaaaaataagaatacatactgtatgc

Downstream sequence

ttccatttatataaaaatctagaaaatagaagcaaacctatcatgacagaaagcagatccttggctgcctgggaaggtaaaaaggggactggtgaagggc

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.