Basic Information
VIS ID
TVIS44009273
Fusion event
HTLV-1-GALK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
49621599/49329402 (Hg38)
End
49621599/49329402 (Hg38)
Orient
+
Location type
UTR3
Target gene
GALK2
miRNAs that regulate target gene
hsa-mir-148a-5p ; hsa-mir-4474-5p ; hsa-mir-3613-3p ; hsa-mir-500a-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p ; hsa-mir-421 ; hsa-mir-4709-5p ; hsa-mir-34c-3p
Nearest miRNA
hsa-mir-10393/Upstream/160249; hsa-mir-11181/Downstream/1030927;
Nearest TSS
ENST00000557528/Upstream/9720; ENST00000617563/Downstream/4900;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/173532, chr15-CpG: 54/Downstream/291386
Upstream sequence
TGGACTATAGGAAGCACTTTCTGAATTATGTAATGATTTGGACCAAAAAGTATTTTGCTGAAATACTCAGGTAATTGAGATAGCAATGGTTTTATGGCAT
Downstream sequence
GAATTATCCAAAAAAATATCAGAATTACTTATTATTCTGTGATTTCATTAGCTCATTAATGTTTAACTCACAGATTGGGCATCACCATCTAGAATTTCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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