Basic Information
VIS ID
TVIS44009274
Fusion event
HTLV-1-AAGAB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
67503451/67211113 (Hg38)
End
67503451/67211113 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
AAGAB
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-92a-3p ; hsa-mir-7856-5p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4477b ; hsa-mir-4799-5p ; hsa-mir-651-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-3691-3p ; hsa-mir-3184-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-1323 ; hsa-mir-1-5p ; hsa-mir-548o-3p
Nearest miRNA
hsa-mir-10393/Upstream/714079; hsa-mir-11181/Downstream/1590737;
Nearest TSS
ENST00000557528/Upstream/24451; ENST00000560497/Downstream/10089;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/144689, chr15-CpG: 62/Downstream/43338
Upstream sequence
GCCAGATACCTGGTCATACAGAGATATCAAAAGAGAGAAACTTCGCAGTGTCCTTCCTTCTTCCTTTCACTTGGGAAGATCTGCCTTTTAAACTGGGATG
Downstream sequence
AAGCCTCAAATGTGGCCTGCTAGGCTGTAGCCTGCAGATTTCTGGAGCCTGACTCTCGCCACGGAGGCAGTCATATGTAGCTATCAACCCAGTACCTCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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