Basic Information
VIS ID
TVIS44009278
Fusion event
HTLV-1-NTRK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
88535818/87992587 (Hg38)
End
88535818/87992587 (Hg38)
Orient
+
Location type
Intronic
Target gene
NTRK3
miRNAs that regulate target gene
hsa-mir-765 ; hsa-mir-485-3p ; hsa-mir-128-3p ; hsa-mir-9-5p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-617 ; hsa-mir-345-5p ; hsa-mir-384 ; hsa-mir-330-3p ; hsa-mir-198 ; hsa-mir-625-5p ; hsa-mir-509-3p ; hsa-mir-151a-3p ; hsa-mir-185-5p ; hsa-mir-768-5p ; hsa-mir-615-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-410-3p ; hsa-mir-4776-3p ; hsa-mir-192-3p
Nearest miRNA
hsa-mir-10393/Upstream/46319; hsa-mir-1179/Downstream/615520;
Nearest TSS
ENST00000557528/Upstream/13784; ENST00000569588/Downstream/106678;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/2151703, chr15-CpG: 36/Downstream/262836
Nearest cancer related gene
NTRK3(OG, No orient, 0)
Upstream sequence
GAACTGTTTCAGACGCATACACTACAATGAAATGGTTCATGGATTTATTTTTCATTTCTTAATAAGACTATTTGGAAAAAAAAACCaacaaccaatatct
Downstream sequence
ataagcactttcacttgcccaggcaatgagcaaagtgctgtgcatggattttctaatctgaccttctcagcatccctatgaggggagaactggtatggac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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