Basic Information
VIS ID
TVIS44009295
Fusion event
HTLV-1-TMEM220-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10640416/10737099 (Hg38)
End
10640416/10737099 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA17A
Target gene
TMEM220-AS1
Nearest miRNA
hsa-mir-1253/Upstream/2550095; hsa-mir-10226/Downstream/1344800;
Nearest TSS
ENST00000595228/Upstream/6783; ENST00000582334/Downstream/31890;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/6926, chr17-CpG: 244/Downstream/503071
Upstream sequence
ACTGGAGAGGGTGGAAGGGGTCATCTGTAGACCAGGGGCTCAATTCTCCAAAGGCTGAAGGGGTGATGTTTGAGGTCCTCCTTTGATGCCATTCTTCTTA
Downstream sequence
TGTCTTAGCTATTTTAAAGACCAGGAAGATTCTCCACTCATGCCCTTGACTTTTAGAGCCAATTAGATGAAGCTGTATTTGGAGGTAGGAAGAGAAGTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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