Basic Information
VIS ID
TVIS44009313
Fusion event
HTLV-1-DSC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
28579592/30999626 (Hg38)
End
28579592/30999626 (Hg38)
Orient
+
Location type
Intronic
Target gene
DSC3
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-32-5p ; hsa-let-7d-5p ; hsa-let-7a-5p ; hsa-mir-195-3p ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-221-5p ; hsa-mir-340-3p ; hsa-mir-3613-3p ; hsa-mir-3681-3p ; hsa-mir-4793-5p ; hsa-mir-4794 ; hsa-mir-548c-3p ; hsa-mir-664a-5p ; hsa-mir-6771-3p ; hsa-mir-6827-3p ; hsa-mir-8073
Nearest miRNA
hsa-mir-1-2/Upstream/700666; hsa-mir-122/Downstream/4592111;
Nearest TSS
ENST00000575820/Upstream/18709; ENST00000582307/Downstream/7292;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/2821415, chr18-CpG: 128/Downstream/41897
Nearest cancer related gene
DSC3(TSG, No orient, 0)
Upstream sequence
TATTTCTAAGTGAATAAAAGAGGAATTTAAAATAAACTAAAAGCAATGCTGAGCCTACAGGGCTAGCTTTCATACTTTTATTCTCTGCTCCTTTCTGTCC
Downstream sequence
TCCTCCATCCACATTTCCCAAAGTTCCTTCTCACAGGGTATCAACAACTCTTTATCCATGTCAATAATTTCTAGGTTTACTTTTCCAGTCCTGATTATTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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