VISDB - VIS Detail

Basic Information

VIS ID

TVIS44009315

Fusion event

HTLV-1-KIAA1328 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr18

Cytoband

q12.2

Reference genome

GRCh37/hg19

Start

34761478/37181515 (Hg38)

End

34761478/37181515 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA18A

Target gene

KIAA1328

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-1288-5p ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714 ; hsa-mir-665 ; hsa-mir-6741-5p ; hsa-mir-6514-3p ; hsa-mir-6771-5p ; hsa-mir-7977 ; hsa-mir-6748-5p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-7160-5p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6746-5p ; hsa-mir-5690 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-6888-5p

Nearest miRNA

hsa-mir-1-2/Upstream/1247373; hsa-mir-122/Downstream/475620;

Nearest TSS

ENST00000575820/Upstream/114175; ENST00000601437/Downstream/48064;

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/352189, chr18-CpG: 28/Downstream/62320

Upstream sequence

CAATAGAATGCATGGAAATTCTTAGGTGTTTGATGAAAAGATACTGCTTTTAGTTAAGTCATGATGTTGGGCTAATACTGTAATTCCCACTGTTAAAAGC

Downstream sequence

CATTAATATAAGAATCCATTCCTCTTATACACACTGGTTTATAGTGTGTAAGTTAGGAAAATAAAGACAAATAGGCTAGGCAGAAATAATAACGATGTAG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.