Basic Information
VIS ID
TVIS44009319
Fusion event
HTLV-1-MBD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
51735344/54208974 (Hg38)
End
51735344/54208974 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
MBD2
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-375 ; hsa-mir-221-5p ; hsa-mir-224-5p ; hsa-mir-302a-3p ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-4795-3p ; hsa-mir-331-5p ; hsa-mir-202-3p ; hsa-mir-4678 ; hsa-mir-126-5p ; hsa-mir-618 ; hsa-mir-4458 ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-let-7b-5p ; hsa-let-7d-5p ; hsa-let-7a-5p ; hsa-let-7e-5p ; hsa-let-7i-5p ; hsa-let-7f-5p ; hsa-let-7c-5p ; hsa-let-7g-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-221-3p
Nearest miRNA
hsa-mir-1-2/Upstream/971784; hsa-mir-122/Downstream/1270247;
Nearest TSS
ENST00000575820/Upstream/3953; ENST00000577612/Downstream/15643;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1866622, chr18-CpG: 59/Downstream/15425
Upstream sequence
ATAATTTGAACTCAATTAAAAGGCTATACTCACGAAATGTGATCACTTATGTTTATCATCTAGATTAGCAGTTCATCAGCAGTTTAACACGGCTTCATAT
Downstream sequence
TATTTCTATTGTTTATTAATTTTAAAAATGAAATGGGGggccaggcacggtggctcacacctgtaatcccagcactttgggaggccaaggagggcggatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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