Basic Information
VIS ID
TVIS44009325
Fusion event
HTLV-1-ADGRE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14882725/14771913 (Hg38)
End
14882725/14771913 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ADGRE2
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-10395/Upstream/242273; hsa-let-7e/Downstream/407370;
Nearest TSS
ENST00000633603/Upstream/63919; ENST00000248072/Downstream/461;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/199731, chr19-CpG: 92/Downstream/207291
Upstream sequence
tacttttagtagagacagggtttcaccatgttggccaggatagtctcgatctcctgaccccgtgatccatccgcctcggcctcccaaagtgctgggatta
Downstream sequence
cagTGCATAATAACGTTTAAAGAATGAAGATGCCTGTagcacctgctgtgtgctgggctctgttagaagcacctattctttccttggtcctcctagaagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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