Basic Information
VIS ID
TVIS44009337
Fusion event
HTLV-1-ADCY3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
25048945/24826076 (Hg38)
End
25048945/24826076 (Hg38)
Orient
+
Location type
Exonic
Target gene
ADCY3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1301-3p ; hsa-mir-1296-5p ; hsa-mir-877-5p
Nearest miRNA
hsa-mir-3125/Upstream/5477571; hsa-mir-10b/Downstream/502564;
Nearest TSS
ENST00000437798/Upstream/466; ENST00000421904/Downstream/5657;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/32318, chr2-CpG: 129/Downstream/93527
Upstream sequence
CAGGGCTGCTTCTCAGGAGGCCCTGTGGGCTGTGGGCACAGAGCGGGGATCGTGCAGGCGGCACTCACGTGGCGGGAGAAGTAGTAGAAGCTGAGCATCA
Downstream sequence
TGAGGAACACCATCACCGTCATAGAGTACTTGGAAGGCACCAGGGGCAGCCTGCTGGGCAGAGCGTGTGCAACTGAAAGGGCTGTCATCTGCCTCCTGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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