Basic Information
VIS ID
TVIS44009341
Fusion event
HTLV-1-COMMD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
62228706/62001571 (Hg38)
End
62228706/62001571 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
COMMD1
miRNAs that regulate target gene
hsa-mir-205-3p
Nearest miRNA
hsa-mir-1301/Upstream/1614126; hsa-mir-10b/Downstream/204255;
Nearest TSS
ENST00000437798/Upstream/592; ENST00000444166/Downstream/134274;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/112716, chr2-CpG: 157/Downstream/193485
Upstream sequence
CAGTTTAATCTTATGTACAGTGCTTCTTTTCCCAACAGTTACAGCAGTCATTATAGCAGATAATTTTAATGTCTATATGGTTTTTCTTGAAGTCATTCAC
Downstream sequence
TTTGTGTTCCAGATGACTGCCAGCTCAGACTTTTAATGATCTGGCTTATGTCTTTGGGGAAAAAAAAAGAAACTGGTAATTAGGAAGAGAAAACCCAGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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