Basic Information
VIS ID
TVIS44009344
Fusion event
HTLV-1-MOB1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
74394544/74167417 (Hg38)
End
74394544/74167417 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
MOB1A
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-181a-5p ; hsa-let-7b-5p ; hsa-mir-93-5p ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-548v ; hsa-mir-6857-3p ; hsa-mir-6855-3p ; hsa-mir-4513 ; hsa-mir-6507-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-186-5p ; hsa-mir-5197-3p ; hsa-mir-3682-5p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-6514-3p ; hsa-mir-1295a ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-1295b-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/3914412; hsa-mir-10b/Downstream/923395;
Nearest TSS
ENST00000437798/Upstream/19372; ENST00000488086/Downstream/10897;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/19287, chr2-CpG: 84/Downstream/10808
Nearest cancer related gene
MOB1A(TSG, No orient, 0)
Upstream sequence
tcactgcaacctccgcttcccgggttcaagcaattctcctgcctcagcctcccaagtagttcggattacaggtgcatgccaccacgcccagctaattttg
Downstream sequence
ttttggtatttttagtagagacagggtttcaccatgttggccaggctggtcttgaactcctgacctcatgatccactcgcATGTAACAGCAGGAAAATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate