Basic Information
VIS ID
TVIS44009352
Fusion event
HTLV-1-ATOH8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86016951/85789828 (Hg38)
End
86016951/85789828 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA2S ; FRA2L
Target gene
ATOH8
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-124-3p ; hsa-mir-6720-3p ; hsa-mir-2277-3p ; hsa-mir-3917 ; hsa-mir-1304-3p ; hsa-mir-6078 ; hsa-mir-4639-3p ; hsa-mir-603 ; hsa-mir-1184 ; hsa-mir-1205 ; hsa-mir-17-3p ; hsa-mir-2278 ; hsa-mir-2467-3p ; hsa-mir-3158-5p ; hsa-mir-3678-3p ; hsa-mir-375 ; hsa-mir-3976 ; hsa-mir-4273 ; hsa-mir-4459 ; hsa-mir-4677-5p ; hsa-mir-4695-5p ; hsa-mir-4722-5p ; hsa-mir-485-5p ; hsa-mir-544a ; hsa-mir-6165 ; hsa-mir-6739-3p ; hsa-mir-6884-5p ; hsa-mir-7156-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/6151; hsa-mir-10b/Downstream/403198;
Nearest TSS
ENST00000437798/Upstream/8794; ENST00000366278/Downstream/25302;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/17322, chr2-CpG: 104/Downstream/98639
Upstream sequence
tgtgcaggcaaggttgaagccgctgGTCTAAGTGGGGTCTGGTCTACGATAAGAAAGTGACTTTGAGCCATCGATTTGGGAGACAGGCTCTGGGTGGATG
Downstream sequence
TGTGTGTGTGCACACATATGTATGTATGTGGATGACTAAAAGTGCATGCTCTCCTCTCCTTTCCCAGCTTCCTCTCCAGCACAGCAACTTGTGTTCGTAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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