Basic Information
VIS ID
TVIS44009357
Fusion event
HTLV-1-SLC9A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
103299637/102683178 (Hg38)
End
103299637/102683178 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
SLC9A2
miRNAs that regulate target gene
hsa-mir-16-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/250812; hsa-mir-10b/Downstream/6458312;
Nearest TSS
ENST00000437798/Upstream/63471; ENST00000467657/Downstream/1120;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/63083, chr2-CpG: 31/Downstream/53501
Upstream sequence
CTCCGGAGATTGCAGGATTTCCGAGGTTTGCATGCAAATCACATTCACCTATAAAAATCATTCGATGATGTTGTAGTCTTGGGCAGAAGAGTAGAGCCAT
Downstream sequence
AATTTAGCTCTTAAGTGCTATCTCTTGCATTCTGATTAAGATCATTGTTAGGTTTCAATAGAAGCTGAATCTTCCCTTTCAGAATCACTGCTTGTGCAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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