Basic Information
VIS ID
TVIS44009370
Fusion event
HTLV-1-PPIG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
170496069/169639559 (Hg38)
End
170496069/169639559 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPIG
miRNAs that regulate target gene
hsa-let-7e-5p ; hsa-mir-525-3p ; hsa-mir-510-3p ; hsa-mir-3161 ; hsa-mir-4738-3p ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-580-5p ; hsa-mir-5583-5p ; hsa-mir-6838-5p ; hsa-mir-3129-3p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-340-5p ; hsa-mir-4795-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-6507-5p ; hsa-mir-186-5p ; hsa-mir-3133
Nearest miRNA
hsa-mir-128-1/Upstream/1056541; hsa-mir-10b/Downstream/5528074;
Nearest TSS
ENST00000437798/Upstream/8122; ENST00000476919/Downstream/41765;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/54728, chr2-CpG: 59/Downstream/54714
Nearby gene
PPIG(+1815) ;
Upstream sequence
TCTGATCCCAGAGCTTTATCTACTAAAAATTATACATAAGGATTTCCAAATCTTAGAGTTTCAAAAAGTAACCATAGGGAAAAAAATTGTAGTAATTTCT
Downstream sequence
ATAGGCAATATTCTGTTTGGGTTATCAAAAGAGCAACTCCATGCTCCGCATTATTTATAGTCCTTATTTTAAAGTTTTATTAGCTCTCTTTACAGAACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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