Basic Information
VIS ID
TVIS44009415
Fusion event
HTLV-1-CADPS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
62552453/62566778 (Hg38)
End
62552453/62566778 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
CADPS
miRNAs that regulate target gene
hsa-mir-5096 ; hsa-mir-377-3p ; hsa-mir-4643 ; hsa-mir-8485 ; hsa-mir-8064 ; hsa-mir-335-3p ; hsa-mir-561-3p
Nearest miRNA
hsa-let-7g/Upstream/1948908; hsa-mir-12124/Downstream/4658686;
Nearest TSS
ENST00000440867/Upstream/15889; ENST00000465262/Downstream/18468;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/188137, chr3-CpG: 127/Downstream/307164
Upstream sequence
caagaattgaaagagaagacctgagttgtcatcctggctcccccattatctttgtgatgatgggactctcacgtcacctctgtgtgtcacagAGGTTGTT
Downstream sequence
AAGGGAGAAATCTGATTCAGGCTGAAACAGATTTTTTTGGGGGGATGGATGTCCCCAACATACCTTGACAGCTCTTTAAAGTTAATGAGAATCATATGTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate