Basic Information
VIS ID
TVIS44009429
Fusion event
HTLV-1-ABHD10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
111701261/111982414 (Hg38)
End
111701261/111982414 (Hg38)
Orient
+
Location type
Intronic
Target gene
ABHD10
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-607 ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-3671 ; hsa-mir-515-5p ; hsa-mir-4766-5p ; hsa-mir-136-5p ; hsa-mir-6884-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-let-7g/Upstream/2379517; hsa-mir-12124/Downstream/130387;
Nearest TSS
ENST00000440867/Upstream/3361; ENST00000494932/Downstream/16250;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/3118, chr3-CpG: 15/Downstream/103604
Upstream sequence
TATTTGATCACTGTTTATCTAAAAGTAATACATGTATTTAAAAGTATCATAATGCAAATTTCTGCTGAGTTTTCTCTTCCCTCTCCTGTAATCTGAATAT
Downstream sequence
GTATAAGCATAAATAGGGATAAGTGGTACTTAACTCAAGCTTGATTTTATAATTCCTAATTTTTCACACTGAGAGTTATTTTAGTAAATAACTTTATGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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