Basic Information
VIS ID
TVIS44009434
Fusion event
HTLV-1-WWTR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
149373424/149655637 (Hg38)
End
149373424/149655637 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
WWTR1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-18a-5p ; hsa-mir-374a-3p ; hsa-mir-488-3p ; hsa-mir-3148 ; hsa-mir-361-5p ; hsa-mir-4635 ; hsa-mir-873-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5682 ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-101-5p ; hsa-mir-6871-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-3121-3p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4746-3p ; hsa-mir-4284 ; hsa-mir-383-3p
Nearest miRNA
hsa-let-7g/Upstream/15217731; hsa-mir-1224/Downstream/1910239;
Nearest TSS
ENST00000440867/Upstream/79385; ENST00000466836/Downstream/1383;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/525456, chr3-CpG: 130/Downstream/1285
Nearest cancer related gene
WWTR1(OG, No orient, 0)
Upstream sequence
AGCACATGTCCAAACTATCACTCAATAACCCAGAGAAGACCAGCTGTGGCATAAATGACCATCAAGTCTGTTTCAGAATCTCAGCATTACACCAATCTCA
Downstream sequence
GAAACAACAAAAGAACTCCTTGGACAAGATATCAACAGCCTTGAGATGGGGAAGTAATAAGAATTGGTCACTGGTATGAATCAATGGGCTCACTATAGTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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