Basic Information
VIS ID
TVIS44009438
Fusion event
HTLV-1-PRKCI integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
169975135/170257347 (Hg38)
End
169975135/170257347 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRKCI
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-505-5p ; hsa-mir-93-5p ; hsa-mir-3613-3p
Nearest miRNA
hsa-let-7g/Upstream/1705398; hsa-mir-1224/Downstream/165756;
Nearest TSS
ENST00000440867/Upstream/34982; ENST00000488541/Downstream/22798;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/34357, chr3-CpG: 141/Downstream/99518
Nearest cancer related gene
PRKCI(OG, No orient, 0)
Upstream sequence
cgagacacaggatttcttaatagtgggcaactttgtcagggactgcaagagagatcacctagaataaggactgaaaagatgtcataggtttcagcagctg
Downstream sequence
gtttcatgacctttgcaaccgcagttttggtggagtgtttgggctaaaacctggcagcagcattttgagaaatgtgtggaaggtaagaacatggagaaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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