Basic Information
VIS ID
TVIS44009445
Fusion event
HTLV-1-EVC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
5704476/5702749 (Hg38)
End
5704476/5702749 (Hg38)
Orient
-
Location type
Intronic
Target gene
EVC2
miRNAs that regulate target gene
hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3942-3p ; hsa-mir-6873-3p ; hsa-mir-5100 ; hsa-mir-4722-5p ; hsa-mir-6721-5p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-5088-3p ; hsa-mir-6729-3p ; hsa-mir-4768-3p ; hsa-mir-1245b-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p
Nearest miRNA
hsa-mir-4800/Upstream/3452593; hsa-mir-12113/Downstream/220526;
Nearest TSS
ENST00000502981/Upstream/264832; ENST00000514919/Downstream/5818;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/134125, chr4-CpG: 56/Downstream/5509
Upstream sequence
ACAGTGCCCTTTTAGACCATCTGGGAAATGGTTGTAATTGCCTCTTCTCTCTTTGTAAGAAGAAGGGATGATAAATTCGCACAGAAATCTTGTGTTCAGG
Downstream sequence
TTCATGAAGCACTTTCTTGTAGAGCCTAGACACCGACAGCAAGTGCTTTGGGTTAGACAAGTCTGGGTGGACATCTTCACCTCACCTGGAAtcactgtgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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