Basic Information
VIS ID
TVIS44009448
Fusion event
HTLV-1-CC2D2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.32
Reference genome
GRCh37/hg19
Start
15548854/15547231 (Hg38)
End
15548854/15547231 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
CC2D2A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-92a-3p ; hsa-mir-544a ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-340-5p ; hsa-mir-555 ; hsa-mir-873-3p ; hsa-mir-6861-5p ; hsa-mir-4329 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4463 ; hsa-mir-32-3p ; hsa-mir-583 ; hsa-mir-186-5p ; hsa-mir-3133
Nearest miRNA
hsa-mir-12113/Upstream/1919274; hsa-mir-12115/Downstream/4981044;
Nearest TSS
ENST00000502981/Upstream/10246; ENST00000512202/Downstream/3507;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/542094, chr4-CpG: 145/Downstream/107510
Upstream sequence
TTCTTTTCTTTTGTACCTTTACAATATTCTGTGATTTTTTAAACttttttattgatacataataattgtatgtatttatggggtacatgtggtattttga
Downstream sequence
tacatgaatagaatgtataatgatcaaatcagggtatttagaatatctattacctcaaacatttatcatttgtgttgcagacattttaaatcttctcttc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate