Basic Information
VIS ID
TVIS44009461
Fusion event
HTLV-1-SPATA18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
52944621/52078455 (Hg38)
End
52944621/52078455 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPATA18
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-510-3p ; hsa-mir-203a-3p ; hsa-mir-7977 ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-3938 ; hsa-mir-6888-5p
Nearest miRNA
hsa-mir-12113/Upstream/4425712; hsa-mir-1243/Downstream/634227;
Nearest TSS
ENST00000502981/Upstream/111; ENST00000503051/Downstream/549911;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1373, chr4-CpG: 141/Downstream/580342
Upstream sequence
AGTCTGGATATGTGTTTATAACATAAACACTAGACTGATAATGTTCTCTTATTTCTTGACCAGTAATGTGATATTGCTATGGGCTTATAGCAGGGGATTT
Downstream sequence
ATTTCCTTCAATTTCTGCACTGTCCTGCTTCCTGCACTCAGAATTTCTAGAATAATAGTCAACTGTCTTGATGTTAGTGAGCATGGATTATTATATGTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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