Basic Information
VIS ID
TVIS44009479
Fusion event
HTLV-1-HSPA4L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q28.1
Reference genome
End
128706587/127785432 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-3646 ; hsa-mir-3688-3p ; hsa-mir-3908 ; hsa-mir-5093 ; hsa-mir-6792-5p ; hsa-mir-6838-5p ; hsa-mir-448 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-937-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5702 ; hsa-mir-6889-3p ; hsa-mir-6849-3p ; hsa-mir-3934-5p ; hsa-mir-1208 ; hsa-mir-6760-3p ; hsa-mir-6504-3p ; hsa-mir-552-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-3664-5p ; hsa-mir-5089-5p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-6853-5p ; hsa-mir-619-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4438 ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-361-5p ; hsa-mir-889-3p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-2115-3p ; hsa-mir-3074-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-1183 ; hsa-mir-6878-3p ; hsa-mir-7641 ; hsa-mir-378a-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-4695-3p ; hsa-mir-4707-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-212-5p ; hsa-mir-6894-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-5001-3p ; hsa-mir-4312 ; hsa-mir-4763-5p ; hsa-mir-6778-3p ; hsa-mir-4680-5p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-9-3p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-3529-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-1289 ; hsa-mir-215-3p ; hsa-mir-3194-3p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-431-5p ; hsa-mir-4534 ; hsa-mir-500b-3p ; hsa-mir-5691 ; hsa-mir-5693 ; hsa-mir-6514-5p ; hsa-mir-6773-3p ; hsa-mir-6805-3p ; hsa-mir-6879-3p ; hsa-mir-8082 ; hsa-mir-924
Nearest miRNA
hsa-mir-12113/Upstream/2278125; hsa-mir-1305/Downstream/15558028;
Nearest CpG islands
Upstream sequence
ACATTAAAAGGTGAAATTAAAAATTTAATTCCTCCAGATGGTTTTCTGTGTGTGTTTTCAAAGGGAAGGGGAAGTATTTACTTTATGTTTAGTAACCttt
Downstream sequence
ttctttttttctttttttttttaagacgtagtcttgctcttgttgcccaggctagagtgcagtggcgcgttttcagctcactgcaacctccgcctcctgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate