Basic Information
VIS ID
TVIS44009489
Fusion event
HTLV-1-ADAMTS16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.32
Reference genome
GRCh37/hg19
Start
5279730/5279617 (Hg38)
End
5279730/5279617 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS16
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-4277/Upstream/3570749; hsa-mir-10397/Downstream/1548236;
Nearest TSS
ENST00000502646/Upstream/44580; ENST00000505464/Downstream/141047;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/138789, chr5-CpG: 18/Downstream/23533
Upstream sequence
tccacagtggttcttttcaatttggggaaaaaagattttattaatactctccttcatttgtttatgctcttgccttctgaactctaacacagtagacaaa
Downstream sequence
tgttatgatgttcttgtgttttcttttcagatgtccatctctttgtctttttatcttggaagtttttttgaattttatcttccaggttttctgctttttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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